R packages by annahutch

fcfdr - Flexible cFDR

Provides functions to implement the Flexible cFDR (Hutchinson et al. (2021) <doi:10.1371/journal.pgen.1009853>) and Binary cFDR (Hutchinson et al. (2021) <doi:10.1101/2021.10.21.465274>) methodologies to leverage auxiliary data from arbitrary distributions, for example functional genomic data, with GWAS p-values to generate re-weighted p-values.

Last updated 3 years ago

5.38 score 6 stars 9 scripts 196 downloads

corrcoverage - Correcting the Coverage of Credible Sets from Bayesian Genetic Fine Mapping

Using a computationally efficient method, the package can be used to find the corrected coverage estimate of a credible set of putative causal variants from Bayesian genetic fine-mapping. The package can also be used to obtain a corrected credible set if required; that is, the smallest set of variants required such that the corrected coverage estimate of the resultant credible set is within some user defined accuracy of the desired coverage. Maller et al. (2012) <doi:10.1038/ng.2435>, Wakefield (2009) <doi:10.1002/gepi.20359>, Fortune and Wallace (2018) <doi:10.1093/bioinformatics/bty898>.

Last updated 3 years ago

3.68 score 6 stars 16 scripts 177 downloads